Mechanism of Susceptibility of Eats to Audiogenic Seizure
نویسنده
چکیده
x CHAPTER I GENERAL INTRODUCTION 1 Seizures in Man 1 Occurrence 1 Etiology 1 Animal Models of Convulsive Disorders 4 Seizure Models Based on Electrical Stimulation ... 5 Seizure Models Based on Chemical Stimulation .... 7 Seizure Models Based on Cortical Lesions 7 Seizure Models Based on Genetic Determinants .... 8 Putative Neuromediators in Seizure Activity 10 Catecholamines 10 5-Hydroxytryptamine (5-HT) 12 Y-Aminobutyric Acid (GABA) . . . . 12 Statement of Problem 13 II GENERAL PROCEDURES 15 Audiogenic Seizure Model 15 Animal Selection 15 Characteristic Response .... 16 Sound Stimulation Technique 16 Evaluation of Response 18 Electrically-Induced Seizures 18 Maximal Electroshock Seizure Threshold 18 Minimal Electroshock Seizure Threshold 20 Localized Bipolar Stimulation of the Brain ..... 20 Chemical Injections into the Brain 22 Surgical Preparation of Animals 23 Bipolar Stimulating and Recording Electrodes .... 23 Cortical Electrodes ................ 23 Subcortical Cannulae 23 Electrolytic Lesions 23 Histological Technique 24
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